Endocrine Abstracts

Cytosolic calcium signalling controls a vast number of cellular functions, such as contraction, secretion, cell growth and cell division. The increase of [Ca2+]i evoked by G-protein coupled receptor activation has two closely related components, i.e. the rapid phase of inositol 1,4,5-triphosphate-mediated Ca2+ release from ER stores, and followed by Ca2+ entry through store-operated channels (SOCs) in plasma membrane. Orai and STIM p...